The Holy Quran, can be an encyclopedia of sciences and a guide for humanity in reach of the goals, and solving problems in all of the sciences. Physiology is not separate from the mentioned cases. Training adaptations in exercise physiology is the result of basic training, with the understanding of intensity and difficulty, as well; Convenience and openness are concurrent, consecutive and combined, and this basic sequence and order is expressed in Ansharah. The important principles in physiology have been expressed in these verses with special delicacy about fourteen hundred years ago. Understanding the principles of various sciences in the Holy Qur'an and producing science requires motivation, understanding and meditation on the verses, mastery of a specialized scientific subject. We did not observe any researches in term of exercise physiology in various papers and electronic media. According to view of Shia and Sunni interpretations, with emphasis on verses 5 and 6 Surah Ansharah, the results are consistent with the stages resulting from physiological adaptations resulting from long-term continuous exercises, which gradually progress with the passage of time and the progress of human science, research, and technology. The interaction between sciences, in different specialized trends, and the ability to make logical and principled generalizations are definitely very effective and efficient in the deep understanding of Quranic verses and expressions. The Holy Qur'an will be explained with the passage of time and we will realize its novelty.